Centronuclear Myopathy

Centronuclear myopathies (CNM) are a group of congenital myopathies where cell nuclei are abnormally located in skeletal muscle cells.  In CNM the nuclei are located at a position in the center of the cell, instead of their normal location at the periphery.   Symptoms of CNM include severe hypotonia, hypoxia-requiring breathing assistance, and scaphocephaly.  Among centronuclear myopathies, the X-linked myotubular myopathy form typically presents at birth, and is thus considered a congenital myopathy. However, some centronuclear myopathies may present later in life.  (Adapted from wikipedia)


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