Colon Histology

The large intestine constitutes the terminal part of the digestive system. It is divided into three main sections: cecum including the appendix, colon, and rectum with the anal canal. The primary function of the large intestine is the reabsorption of water and inorganic salts. The only secretion of any importance is mucus, which acts as a lubricant during the transport of the intestinal contents.

The surface of the mucosa is relatively smooth as there are no plicae circulares or intestinal villi. Crypts of Lieberkühn are present and usually longer and straighter than those of the small intestine. Goblet cells account for more of the epithelial cells than in the small intestine.

There is only little lamina propria squeezed between the glands. The muscularis mucosa again forms two layers. (adapted from U of W Australia)

NYU virtual microscopy (here)

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