Pacinian Corpuscle

Pacinian corpuscle or Lamellar corpuscle are large, ovoid structures up to 1 mm in diameter found in the dermis and hypodermis of the skin and also in the connective tissue associated with bones, joints, and internal organs.  They respond primarily to pressure and vibration and are composed of a myelinated nerve ending surrounded by a capsule.   The unmyelinated portion of the axon extends toward the opposite pole from which it entered and its length is covered by flattened Schwann cell lamellae that form the inner core of the corpuscle. The remaining bulk of the capsule, or outer core, is comprised of a series of concentric, onionlike lamellae with each layer separated by an extracellular fluid similar to lymph. Each lamella is composed of flattened Schwann cells and endoneurial fibroblasts. In addition the fluid between each layer, delicate collagen fibers may be present as well as occasional capillaries.  Displacement of the lamellae by pressure or vibrations effectively causes depolarization of the axon, which sends the signal to the central nervous system. (adapted from U of Michigan Histology)

Virtual Microscopy (from U Mich).  another Virtual Microscopy (this slide has very good Meissner’s corpuscles as well)

 Virtual Microscopy (from NYU) has very good pacinian corpuscles

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This entry was posted in Histology, Nervous system, Skin, Special Senses.

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