Peutz-Jeghers Syndrome

Clinical features of Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder, include clusters of melanotic spots on the lips and limbs, polyposis of the gastrointestinal (GI) tract, and propensity to develop neoplasms of the GI tract, ovaries, testes, and other sites. (from Annals of Clinical & Laboratory Science- link)
Image from Annals of Clinical & Laboratory Science (link)       Larger image (link)

Typical brown spots on the soles of the feet of PJS patients

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